One family’s history reveals the mystery of schizophrenia. In a riveting and disquieting narrative, Kolker (Lost Girls: An Unsolved American Mystery, 2013) interweaves a biography of the Galvin family with a chronicle of medicine’s treatment of, and research into, schizophrenia…. Kolker deftly follows the psychiatric, chemical, and biological theories proposed to explain schizophrenia and the various treatments foisted upon the brothers. Most poignantly, he portrays the impact on the unafflicted children of the brothers’ illness, an oppressive emotional atmosphere, and the family’s festering secrets. By the 1980s, the Galvins became subjects of researchers investigating a genetic basis for the illness; those extensive medical records inform this compelling tale. A family portrait of astounding depth and empathy.